Dr. Bob stated, "Protecting your hormonal cascade means starting in your thirties and forties. This is triple for women."

Dr. Bob was a MD internal medicine, orthomolecular doctor, MD psychiatrist, chiropractor, and healer 65 years. He was a diabetic who lived to 108 years with only 1 side effect 2 years before he passed away.

Understanding the hormonal cascade is vital. According to Dr. Bob the hormonal cascade is "using hormones in combination, from the brain down, and monitoring them regularly to ensure they all remain within youthful normal ranges." The hormones are the chemical messengers in the body. They basically run the body. The hormones are produced from top to bottom. This means the hormones at the top are produced first

The key to understanding the hormonal cascade is the top of the cascade is the controller for hormones further downstream. For example, melatonin is the first hormone produced. The rest of the hormones are produced after melatonin. The idea of the hormonal cascade is to ensure that hormones downstream are balanced, by balancing the top of the cascade first, before replacing any hormones further downstream. Therefore it is essential that the top hormone on the cascade, melatonin, starts everything off by being in sufficient supply. For example, if melatonin is low, this may lead to other hormones downstream being depressed. Thus, melatonin is a controller of hormones downstream. So it is vital to have melatonin in sufficient supply.

The next hormone you drop down to that is a controller of other hormones is human growth hormone. Human growth hormone has many functions in the body. In relation to the hormonal cascade, it balances and supports other hormones, including melatonin. Therefore it is vital to balance human growth hormone in order to balance the hormonal cascade.

Another vital hormone, further downstream on the cascade, is DHEA. DHEA is involved in the conversion of cholesterol into the body's steroid hormones. Therefore it is essential that DHEA be in sufficient supply and balanced in order to do the appropriate work of producing the sexual hormones in the right balances. If DHEA is not in sufficient supply, this may disrupt the balances between estrogen, progesterone, testosterone, and other hormones. This could lead to grave danger. Therefore DHEA should be balanced before balancing any other sexual steroid hormone.

Furthermore, Dr. Bob recommended that a woman have her estrogen levels checked and a man have his testosterone levels checked. Although these are at the bottom of the cascade, they are vital to maintaining health. Therefore they should be maintained in sufficient supply and balance as you age.

There are many other hormones not mentioned. Dr. Bob said they were secondary compared to melatonin, human growth hormone, DHEA, thyroid, adrenals, testosterone, and estrogen. These are the vital hormones that must be in sufficient amounts and balanced to control and balance all the other hormones.

The reason the hormonal cascade is essential to understand is because for three decades doctors have been using replacement hormonal therapies without this understanding. The result has been many thousands of wrong therapies leading to grave mistakes. For the past three decades, most doctors replace low hormones with the hormone that is low. For example a low estrogen level would often lead to adding estrogen to increase the level. This has led to many disasters. Increasing estrogen by itself can lead to insufficiency and imbalance with DHEA, progesterone, and testosterone. All the sexual hormones are linked to each other and replacing one changes the balances and sufficiencies of the others. Therefore, in this case, before you add estrogen, you need to add DHEA if it is low. Also you need to check the progesterone and testosterone and add them at the same time as estrogen if they are insufficient or not in balance.

So hormones need to be added in combinations. These combinations lead to feedback situations that aid in balancing each other. This results in more stability in the hormonal cascade. This can result in greater safety when replacing hormones, by keeping the hormones balanced and in the right amounts. The idea of using the right amount of hormone replacement, in hormonal replacement therapy, is to replace only to the lower, optimal, youthful levels the hormones that are low.

To further continue the idea about replacing estrogen in combination with DHEA, progesterone, and testosterone, next is melatonin. Remember melatonin starts off the cascade. It therefore is a controller of DHEA. DHEA will work better in combination with melatonin. So before adding estrogen you need to add melatonin if it is low or not balanced. Also human growth hormone is upstream and it affects DHEA, which is downstream. Therefore human growth hormone should be balanced and in sufficient amounts in order to protect the hormonal cascade further downstream.

The value in understanding the hormonal cascade is to be sure you use only doctors that understand this idea whenever you use hormonal replacement therapy. The doctors who are keeping up with the newest ideas of the hormonal cascade are called the A-4 doctors. These are the anti-aging doctors, who belong to the American Academy of Anti-aging Medicine, the fastest growing group of doctors at the present. They represent cutting edge hormonal science, and they test their own members to ensure they are keeping up with the latest hormonal developments. Another place to get referrals for doctors that understand the hormonal cascade is to contact the Colgan institute at 760-632-7722. Dr. Michael Colgan as written the book, "Hormonal Health." This book will change any man or woman's thinking about the medical establishment and what is the appropriate method for hormonal replacement therapies. Anyone considering hormonal replacement should read this book first!

In conclusion there are many hormonal replacement therapies being used. For example, there are thyroid replacement therapies, adrenal replacement therapies, estrogen replacement therapies, and others. For three decades, until the present, there are still mistakes being made. In order to avoid being a causality you must pick a doctor who understands the concept of replacing hormones in combination, from top to bottom.


Note Ė In order for these anti-aging ideas to be successful, you must use supplements of the highest quality. Dr. Bob often said, "almost all supplement companies produce poor quality." You can consider the product page of this web site. Almost all the products met Dr. Bobís approval. Since he passed away we have attempted to keep the same high standards.

WARNING:  DO NOT STOP ANY TREATMENT OR MEDICATION YOU CURRENTLY USE.  CONSULT WITH YOUR DOCTOR BEFORE STARTING THE USE OF SUPPLEMENTS. 

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The Food and Drug Administration has not evaluated any of the statements contained on this web site. The information contained in this article is not intended to diagnose, treat, cure or prevent any disease. Remember each person's body is different and will react differently to various herbal, vitamin and mineral supplements. Therefore, any supplementation must be administered on an individual basis. Use the information found on this web site as precisely that: Information. You and your doctor must make any final decisions. This information is not meant to replace any doctor and patient consultation. This information should in no way replace your personal physician's advice.

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Page Last Modified: 26 Sep 2004