The symptoms of Parkinson's Disease, such as tremors, rigidity, postural instability, and other disorders of movement, are considered a result of declining levels of the neurotransmitter dopamine. In Parkinson's Disease there is a degenerative process in the brain that leads to a marked decrease in synthesis of dopamine and a resultant drop in its levels in the substantia nigra and corpus striatum (two areas of the brain where dopamine synthesis is important). The lowering of dopamine results in raising the ratio of acetylcholine to dopamine, in cells of the nigrostriatal system. Acetylcholine is the neurotransmitter that stimulates muscle cells. It is considered that the higher ratio of acetylcholine to dopamine leads to over-stimulating muscle cells and this imbalance contributes to the various disorders of movement found in Parkinson's Disease.
Dopamine is the precursor to norepinephrine, a neurotransmitter. Norepinephrine is a precursor to the hormone epinephrine. Norepinephrine and epinephrine are anti-stress chemicals in the body. Obviously there is great stress from Parkinson's Disease. This will lead to the chronic release of epinephrine into the bloodstream. Adrenaline hormones such as epinephrine are designed to be released only in a state of emergency, such as flight or fight, and not chronically as in Parkinson's Disease.
To decrease the amount of dopamine needed as a precursor for epinephrine and norepinephrine, thereby helping to preserve dopamine, you can increase the efficiency of epinephrine. This will result in less depletion of dopamine.
Furthermore, "epinephrine is involved increasing the power of muscles and prolonging the action of muscles (Oxford Dictionary of Biology)," by its ability to activate "the release of glucose from glycogen (stored carbohydrate energy) - (Harperís Biochemistry 25th edition, Page 731). Thus, optimizing the ability of epinephrine may help achieve more muscle control, perhaps reducing motor symptoms of Parkinsonís.
Thus, controlling acetylcholine activation and controlling the overstimulation of epinephrine activity can have important effects involving motor control. If acetylcholine and epinephrine can be calmed down (inhibit), this can help calm down motor symptoms of Parkinson's.
Dr. Bob was a MD internal medicine, orthomolecular doctor, MD psychiatrist, chiropractor, and healer 65 years. He was a diabetic who lived to 108 years with only 1 side effect 2 years before he passed away. Dr. Bob practiced a system of medicine called orthomolecular medicine. It is a system of medicine that uses mainly natural substances that are non-toxic and safe in wide range of doses. It uses mainly herbs and minerals/vitamins.
Dr. Bob advised the following orthomolecular ideas to help calm down the neurotransmitter acetylcholine and the hormone epinephrine:
In conclusion, Parkinson's is a disease of accelerated aging. Motor symptoms, brain degeneration, decrease in cognitive function, and other problems of Parkinson's lead to decline in efficiency and function of the brain and body, which results in further degeneration, aging, and breakdown. This is a downward spiral of declining efficiency and function. Each symptom and problem of Parkinson's needs to be neutralized, in order to slow down the aging process. There is no magic bullet cure. Each specific condition must be dealt with and methods of anti-aging can be used. The ideas in this article are to help in one aspect of Parkinson's, to help inhibit the activation of acetylcholine and the overstimulation of epinephrine. Good luck.
Note Ė In order for these anti-aging ideas to be successful, you must use supplements of the highest quality. Dr. Bob often said, "almost all supplement companies produce poor quality." You can consider the product page of this web site. Almost all the products met Dr. Bobís approval. Since he passed away we have attempted to keep the same high standards.
WARNING: DO NOT STOP ANY TREATMENT OR MEDICATION YOU CURRENTLY USE. CONSULT WITH YOUR DOCTOR BEFORE STARTING THE USE OF SUPPLEMENTS.
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Page Last Modified: 26 Sep 2004