is derived from the essential amino acid histidine. Histamine is an important immune system chemical.
In the initial stages of an immune response, histamine amplifies the
immune response by increasing capillary permeability and smooth muscle
contraction. This enhances the flow
of immune factors to the area of infection.
Subsequently, histamine exerts a suppressive effect on the accumulated
white blood cells in an attempt to contain the inflammatory response.
medicine is a system of medicine practiced by MD’s in over 45 countries in the
world. It is a system of medicine
using mainly natural substances, non-toxic, and safe in a wide range of dose.
It uses mainly herbs and vitamins/minerals.
There is an increasing concern with the safety of antihistamine
medications. Drugs are toxic. Orthomolecular medicine offers natural methods to deal with
high histamine levels.
leader of orthomolecular medicine is Abram Hoffer, MD, and Ph.D.
He has organized orthomolecular conferences for decades, including key
speakers on cutting edge orthomolecular developments. He annually hosts an
orthomolecular conference, which features keynote speakers.
Dr K. Wenzel was a keynote speaker at the annual 29th
orthomolecular conference held in the year 2000.
He has been an orthomolecular doctor for 25 years in Germany.
Dr. Wenzel has treated and observed high histamine levels in patients for
several decades. The following
information is from his keynote speech. The
information offered by Dr. Wenzel was mainly his own clinical experience and
observations over the past several decades.
Dr. Wenzel did not give permission and has no knowledge that ideas from
his keynote speech are being used on RUWC web site.
Wenzel's observations of symptoms for high histamine:
You can test for high histamine levels.
Rapid metabolism, which can often result in a lean body.
Warm hands and feet.
A lot of salvia, which can often result in excellent teeth.
A lot of perspiration.
High libido and easy organism.
Frequent cold and allergies.
Chronic insomnia- need little sleep.
Scarcely reacts to drugs and alcohol.
Dr Wenzel speculates that the drugs and alcohol are a method to
self-medicate. Drugs and alcohol
can help reduce histamine levels.
Chronic depression, perfectionist, and/or power worker.
you have many of these symptoms, you may have high histamine levels.
You can see a doctor and get laboratory analysis to determine your
Wenzel’s methods to help reduce high histamine levels:
Folate acid can increase histamine, therefore consider not using
supplements and foods containing folate acid.
Eat a low protein diet. Histidine
is an amino acid. Eating a low
protein diet reduces the amount of histidine you consume.
Histamine is derived from histidine; thus lower levels of histidine can
result in lower levels of histamine.
Vegetarian diet is better, since less histamine in vegetables.
Consume low alcohol.
Dr. Wenzel often found chromium; zinc, manganese, and vitamin B6 were
deficient. Thus, consider asking
your doctor for laboratory testing for chromium, zinc, manganese, and vitamin B6
levels. If they are out of balance,
consider appropriate supplementation to reestablish balance.
Supplement the amino acid methionine or glycine.
They can inhibit histidine.
Dr. Bob is mentioned many times on this web site.
Dr. Bob was a MD internal medicine, orthomolecular doctor, MD
psychiatrist, chiropractor, and healer 65 years.
He was a diabetic who lived to 108 years with only 1 side effect 2 years
before he passed away.
following are the methods Dr. Bob used for high histamine levels:
Supplement between ½ gram -
1 gram of the amino acid methionine in the AM.
After 5 days, stop it for 4 days. If
needed, resume a 5-day cycle of use and a 4-day cycle you stop.
The time you stop helps to replenish and rejuvenate the bodies’ ability
to process methionine. During
acute stress, take between ½ gram - 1 gram daily, until no longer needed.
Supplement 150 mg N-acetyl-cysteine (NAC) in the AM.
NAC helps decrease mucous.
Supplement OKG. OKG produces
arginine in the body. Arginine
competes with histidine for amino transport.
Competition with arginine for amino transport can inhibit histidine,
which can lead to lower levels of histamine.
Dr. Bob advised OKG instead of arginine for supplementation.
OKG can produce arginine in the body.
OKG is an ammonia scavenger and supplementing amino acids can increase
excess free ammonia in the body. Excess
free ammonia can be harmful. OKG
has the double duty of supplying arginine and scavenging ammonia.
Furthermore, OKG can supply more arginine in the body than arginine
supplementation. The book Optimal
Sports Nutrition, written by one of the world’s most renowned nutritional
scientists, Dr. Michael Colgan, states "alpha-ketoglutarate (AKG) acts in
the body as an ammonia scavenger. Ornithine
also acts as an ammonia scavenger. The
combination of the two (OKG) is a potent way to reduce your ammonia burden (Page
377)." Also the ammonia
scavenging property of AKG is doubly beneficial because excess free ammonia can
be harmful. Dr. Colgan on
ketoisocaproate, "Studies on patients who have been put into a high
catabolic, high ammonia condition by surgery or disease, show that
ketoisocaproate acts as a strong ammonia scavenger." Page 380)."
So AKG can help produce glutamine and scavenge ammonia.
Dr. Bob recommended ¼ to ½ gram in the AM and PM.
Cycle along with methionine.
Supplement the form of niacin called inositol hexanicotinate.
It can cross the blood brain barrier more effectively than niacin. It has no flush, while niacin has a flush.
Niacin can increase cell membrane permeability.
Increasing cell permeability can improve the ability of supplements to
penetrate into cells. Dr. Bob
advised 100 mg of hexanicotinate in the AM along with methionine
Supplement ½ to ¾ hour before meals.
Wait 3 hours after eating protein, before using the supplements described
in this article. The protein may compete with the supplements, inhibiting
Do not supplement lysine. Lysine
also competes with histidine for amino transport, thus can inhibit it.
Dr Bob advised that OKG produced less ammonia than lysine and also
scavenged ammonia. Lysine produces
a lot of ammonia. Therefore Dr. Bob
said OKG was more efficient than lysine, to inhibit histidine.
Supplement ion-exchange whey protein concentrate for some of your protein
needs. Decrease protein meats and
diary products. Whey is a predigested 98% high quality protein product,
meaning it supplies about 98% of the protein you need.
It is low toxic. Dr. Colgan explains, "During evolution humans
developed the separate gut system to absorb dipeptides and tripeptides (amino
acids, the building blocks of protein, linked together as two or three amino
acid bonds) for very special reasons. When
two or more aminos are joined together they carry information.
That information causes physiological responses that do not occur to
single (information-less) aminos." One
important point is the separate gut system.
The separate gut system bypasses normal digestion and therefore spares
many of the processes of digestion. This
will lead to less toxic waste products, making protein supplementation with whey
more efficient and a far less strain on the kidneys.
Also has described, whey powder, which contains amino acids linked
together as two or three amino acid bonds, carries information, which makes the
amino acids help the body work more efficiently.
from RUWC web site:
1-2 grams in AM and PM of vitamin C.
Vitamin C helps regulate white blood cells.
The more efficient white blood cells, the more likely that immune
response to histamine will be more controlled.
Increasing the efficiency of the immune system is a method that can help
control histamine responses.
Natural sources of histidine include rice, wheat, and rye. Consider not eating foods containing histidine
Consider the supplement TMG. It
helps to increase methionine levels in the body.
Orthomolecular doctors have offered the observation in other keynote
speeches at the annual orthomolecular conferences hosted by Abram Hoffer,
vitamin B12 can increase histamine levels. Consult with a nutritional specialist
if you have high histamine levels and are considering supplementing vitamin B-12
Consider asking your doctor for laboratory analysis of your calcium,
magnesium, potassium and sodium levels. Calcium
and magnesium control many of the responses of the sympathetic and
parasympathetic nervous system. Immune
responses that over respond, as in the cases of high histamine levels, can
overly stimulate the sympathetic system and inhibit the parasympathetic system.
You can help to regulate both systems by establishing proper
calcium-magnesium ratios. Potassium and sodium are cofactors of magnesium and
calcium and are important to have them laboratory analyzed.
Regulating these minerals can have an effect on regulating the
sympathetic and parasympathetic system. Consult
with a nutritional expert on appropriate supplementation to reestablish proper
mineral balance if tests show improper levels.
If you can improve regulation of both systems, then you may help inhibit
some of the overly stimulated immune responses that can occur with high
If you supplement magnesium, then consult with a nutritional specialist
to supplement vitamin B6. B6 is a
cofactor of magnesium. If you
supplement vitamin B6, consult a nutritional specialist to supplement magnesium,
a cofactor of vitamin B6.
Consider drinking 12 glasses of distilled water to help detox and support
Consider natural methods to ensure 2 or more bowel movements each day.
This will help improve detox. Detox
is needed from histamine and the effects that result from high histamine levels. You can read the article, “Constipation,” for ideas on
using natural methods to produce bowel movements.
conclusion, there are natural methods to help control histamine levels.
Natural methods often take several weeks to several months to become
effective. You are increasing the
health of cells and this is a process that takes time.
You are building better cells. Good
Note – In order for these nutritional ideas to be
successful, you must use supplements of the highest quality. Dr. Bob often said,
“almost all supplement companies produce poor quality.” You can consider the product page of this web site.
Almost all the products met Dr. Bob’s approval.
Since he passed away we have attempted to keep the same high standards.
WARNING: DO NOT STOP ANY
TREATMENT OR MEDICATION YOU CURRENTLY USE.
CONSULT WITH YOUR DOCTOR BEFORE STARTING THE USE OF SUPPLEMENTS.
Thanks for coming to the web site. Go with the flow and contribute to the music of the motion.
If you are happy with any information found on this web site, please
consider a donation.
The Food and Drug Administration has not evaluate any of
the statements contained on this web site.
The information contained in this article is not intended to diagnose,
treat, cure or prevent any disease. Remember
each person’s body is different and will react differently to various herbal,
vitamin and mineral supplements. Therefore, any supplementation must be administered on an
individual basis. Use the
information found on this web site as precisely that: Information.
You and your doctor must make any final decisions.
This information is not meant to replace any doctor and patient
consultation. This information
should in no way replace your personal physician’s advice.
Direct inquires about the site to the Web master. Remember to refresh the site to view new additions.
Page Last Modified: 23JAN02