Pregnenolone or Progesterone

Many hormone levels in the body start to decline after about age 35 years. Hormones are chemical messengers that run the body. Declining hormone levels result in less efficiency in the body, which leads to a drop in function. Eventually declining function leads to structure changes in the body, which are often expressed in the form of degeneration, disease, aging, and breakdown. Many women learn that their female sexual hormones begin to decline well before menopause is complete.

Of course many women wish to avoid the problems that declining sexual hormones can create, such as greater potential to develop osteoporosis, greater incidence of heart disease in women, greater increase in certain types of cancers, and so on. Women therefore seek to restore sexual hormones with replacement therapy. Many women that seek to restore the sexual hormone progesterone usually encounter several choices. One choice is pregnenolone, a precursor of progesterone. Pregnenlone is made from cholesterol, and then it is handled and processed by the body and produces progesterone and DHEA. Women also have the choice of oral progesterone and topical progesterone for replacement therapy.

Progesterone cream has been shown to be effective replacement therapy for progesterone. Pregnenolone made in the body can also produce progesterone, but supplementation of pregnenolone has not yet been proven effective or safe. Oral progesterone is not effective, since the liver metabolizes it and you can read about it on this web site in the article, "Oral Progesterone Ineffective." Furthermore, using topical progesterone cream eliminates one extra step in restoring progesterone levels, versus using pregnenolone to produce progesterone.

In summary, why use pregnenolone to produce progesterone in the body? It has not yet been shown an effective supplement to produce progesterone. Furthermore, pregnenolone must go through an additional step before it produces progesterone, while using topical progesterone eliminates the need for one more step. Sometimes the body is unable to complete a step such as pregnenolone to progesterone, and using progesterone cream avoids this possibility. Furthermore, topical progesterone cream enters the bloodstream, which mimics progesterone's actions in the body. Pregnenolone enters the oral route and must pass through the liver. The liver metabolizes many substances, reducing and changing them into other substances. Pregnenolone may also be metabolized to some degree by the liver, reducing its levels in the bloodstream, although there is still much to be learned about pregnenolone.

In conclusion, progesterone cream does what it is supposed to do, restore progesterone levels in the bloodstream. Oral pregnenolone may or may not accomplish restoring progesterone levels in the bloodstream. It seems simple to keep it simple, restore progesterone levels with topical progesterone cream.

Note – In order for these anti-aging ideas to be successful, you must use supplements of the highest quality. Dr. Bob often said, "almost all supplement companies produce poor quality." You can consider the product page of this web site. Almost all the products met Dr. Bob’s approval. Since he passed away we have attempted to keep the same high standards.


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The Food and Drug Administration has not evaluated any of the statements contained on this web site. The information contained in this article is not intended to diagnose, treat, cure or prevent any disease. Remember each person's body is different and will react differently to various herbal, vitamin and mineral supplements. Therefore, any supplementation must be administered on an individual basis. Use the information found on this web site as precisely that: Information. You and your doctor must make any final decisions. This information is not meant to replace any doctor and patient consultation. This information should in no way replace your personal physician's advice.




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Page Last Updated: 21JAN02